Will everything still be OK to save the configuration several hours after completion of the backup?
I can't think of a reason why you need to save the configuration after you have done a backup. Is that something you think you have to do to use FFS for backing-up? I would suppose that if you were just testing out a particular configuration you might want to do this if you were satisfied with the results of the test. However, in day-to-day use there is no necessity to save a configuration once a backup is completed.
Your OneDrive questions are above my pay-grade so I can't answer them - don't know anything about that I'm afraid.
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